Structural fluctuations and aging processes in deeply frozen proteins

Biological Systems at Low Temperatures

Автор(и)

  • J. Schlichter Physik-Department E14 and Lehrstuhl für Physik Weihenstephan, Technische Universität München, 40 Vöttinger Str., Freising D-85350, Germany
  • V.V. Ponkratov Physik-Department E14 and Lehrstuhl für Physik Weihenstephan, Technische Universität München, 40 Vöttinger Str., Freising D-85350, Germany
  • J. Friedrich Physik-Department E14 and Lehrstuhl für Physik Weihenstephan, Technische Universität München, 40 Vöttinger Str., Freising D-85350, Germany

DOI:

https://doi.org/10.1063/1.1614196

Ключові слова:

PACS: 87.15.–v

Анотація

Frozen proteins are nonergodic systems and are subject to two types of structural motions, namely relaxation and fluctuation. Relaxation manifests itself in aging processes which slow the fluctuations. Within certain approximations we are able to experimentally separate the aging dynamics from the fluctuation dynamics by introducing two time parameters, namely an aging time ta and a waiting time tw. Both processes follow power laws in time. The fluctuation dynamics shows features of universality characterized by a rather uniform exponent of 1/4. This universality features were shown to be possible due to a random walk on a 1D random trajectory in conformational phase space. A very interesting aspect of protein dynamics concerns the influence of the host solvent on structural motions of the protein cores. We present results for sugar solvents and discuss possible mechanisms.

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Опубліковано

2003-09-01

Як цитувати

(1)
Schlichter, J.; Ponkratov, V.; Friedrich, J. Structural Fluctuations and Aging Processes in Deeply Frozen Proteins: Biological Systems at Low Temperatures. Fiz. Nizk. Temp. 2003, 29, 1049-1056.

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