Low-temperature 1Н NМR spectroscopic study of hydration properties of a hybrid system based on nanosilica, DNA and doxorubicin in the presence of C60 fullerene

Автор(и)

  • V.V. Turov O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine, 17 Gen. Naumov Str., Kyiv 03680, Ukraine
  • Yu.I. Prylutskyy Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str., Kyiv 01601, Ukraine
  • A.P. Ugnivenko O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine, 17 Gen. Naumov Str., Kyiv 03680, Ukraine
  • V.N. Barvinchenko O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine, 17 Gen. Naumov Str., Kyiv 03680, Ukraine
  • T.V. Krupskaya O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine, 17 Gen. Naumov Str., Kyiv 03680, Ukraine
  • N.G. Tsierkezos Technical University of Ilmenau, 25 Weimarer Str., Ilmenau 98693, Germany
  • U. Ritter Technical University of Ilmenau, 25 Weimarer Str., Ilmenau 98693, Germany

DOI:

https://doi.org/10.1063/1.4866907%20

Ключові слова:

SiO2–DNA–Dox–C60 fullerene hybrid system, weakly- and strongly-associated water clusters, Gibbs free energy, 1H NMR spectroscopy.

Анотація

The structure of hydrate cover layers of SiO2–DNA–Dox (where Dox: doxorubicin) and SiO2–DNA–Dox–C60 fullerene hybrids was studied by means of low-temperature 1H NMR spectroscopy in tetrachloromethane. Thehydration properties of SiO2–DNA–Dox nanomaterials combined with fullerenes and their derivatives are extremely important for their further use as therapeutics in cancer treatment and for safety reasons. The findings reveal that the hydration properties of the hybrids differ from those of the solid DNA particulates or SiO2–DNA systems due to the existence of different types of water clusters, namely the weakly- (WAW) and strongly-associated water (SAW) clusters. For SAW clusters the radial distributions as well as the distributions of change in Gibbs free energy due to adsorptive interactions at the surfaces of the investigated systems were obtained.

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Опубліковано

2014-01-21

Як цитувати

(1)
Turov, V.; Prylutskyy, Y.; Ugnivenko, A.; Barvinchenko, V.; Krupskaya, T.; Tsierkezos, N.; Ritter, U. Low-Temperature 1Н NМR Spectroscopic Study of Hydration Properties of a Hybrid System Based on Nanosilica, DNA and Doxorubicin in the Presence of C60 Fullerene. Fiz. Nizk. Temp. 2014, 40, 309-316.

Номер

Том 40 № 3 (2014)

Розділ

Наноструктури при низьких температурах

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